When good cholesterol goes bad
A new study by Harvard School of Public Health (HSPH) researchers has found that a subclass of high-density lipoprotein (HDL) cholesterol, the so-called good cholesterol, may not protect against coronary heart disease (CHD) and in fact may be harmful. This is the first study to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective. The study was published in an online issue of the Journal of the American Heart Association. “This finding, if confirmed in ongoing studies, could lead to better evaluation of risk of heart disease in individuals and to more precise targeting of treatments to raise the protective HDL or lower the unfavorable HDL with apoC-III,” said Frank Sacks, professor of cardiovascular disease prevention at HSPH and senior author of the study. A high level...