CT45, an Unexpected Link Between Hodgkin Lymphoma and Reproductive Germ Cells
Wednesday, February 24, 2010 - 22:28
in Health & Medicine
The laboratory of Dr. Lloyd J. Old of the Ludwig Institute for Cancer Research (LICR), together with Dr. Yao-Tseng Chen at Weill Cornell Medical College and their collaborators, made the finding that CT45, a cancer/testis (CT) antigen normally expressed in testicular germ cells in both prenatal and adult life, is expressed by the Reed-Sternberg cells in most of the classical Hodgkin lymphomas. The finding has implications for diagnostic, prognostic, and therapeutic approaches for Hodgkin lymphoma.