Super-Enhancers Seen as 'Rosetta Stone' for Dialog Between Genes and Disease
Thursday, October 10, 2013 - 11:41
in Biology & Nature
Having recently discovered a set of powerful gene regulators that control cell identity in a few mouse and human cell types, Whitehead Institute scientists are now showing that these regulators--which they named "super-enhancers"--act across a vast array of human cell types and are enriched in mutated regions of the genome that are closely associated with a broad spectrum of diseases.