Molecular Glue Controls Chromosome Segregation in Oocytes

Most trisomic pregnancies arise as a consequence of chromosome missegregation in egg precursor cells called oocytes. Austrian researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences (OAW) aim to understand the molecular causes of female age-dependent chromosome missegregation in oocytes. They have now discovered that a "molecular glue" called cohesin plays an important role in proper functioning of checkpoint control, ensuring correct chromosome segregation and production of euploid eggs.

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