Screening for Matrix Effect in Leukemia Subtypes Could Sharpen Chemotherapy Targeting

Friday, December 5, 2014 - 11:00 in Physics & Chemistry

Jae-Won Shin and David Mooney of Harvard University's Wyss Institute for Biologically Inspired Engineering in Cambridge, MA, describe building a three-dimensional (3D) hydrogel system with tunable stiffness to see how relative stiffness of the surrounding ECM affected the resistance of human myeloid leukemias to chemotherapeutic drugs.

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