CYCLIN-B1/2 and CYCLIN-D1 act in opposition to coordinate cortical stem cell self-renewal and lineage commitment
Friday, June 5, 2020 - 06:40
in Biology & Nature
The capacity of a stem cell population to generate several distinct cell types in a temporally defined manner is fundamental to both organ development and homeostasis. To achieve this, stem cells must carefully balance self-renewal and commitment to cellular differentiation, but how this is regulated at the genetic level has remained unclear.