Photographed: Ratchet-Like Cell Mechanism that Pulls Wounds Shut
Closing Time: In this micrograph of dorsal closure in a fruit-fly embryo, the protein actin is marked red, prominent around the gap in the epithelial cells. The microtubules that give shape to cells are green, and epithelial cells with their microtubules destroyed are blue. Damian BrunnerOne of the steps in fruit-fly development is similar to the healing of wounds. Until recently, scientists believed that when fruit-fly bodies take form during a process called dorsal closure, long strings of the protein actin behaved like the drawstring of a purse, pulling together the epithelial cells that eventually form the fly’s skin. Damian Brunner’s research group at the European Molecular Biology Laboratory in Heidelberg, Germany, however, showed that contractions bringing epithelial cells into the gap were generated by a different set of cells “acting like a primitive muscle.” By taking more microscope pictures per minute and combining these with computer simulations, the researchers...