New data regarding safety of artemisinin combination therapy for pregnant women with malaria

A trial conducted in northwest Thailand has found that it is safe to use artemisinin combination therapy (ACT) to treat pregnant women with malaria, but that efficacy is inferior to single-drug artesunate treatment. The study, published in next week's PLoS Medicine, suggests that the ACT evaluated in the trial, artemether-lumefantrine (AL), may have lower efficacy because drug concentrations were seen to be reduced during pregnancy. The authors suggest that longer, or more frequent, regimens of the drug combination should be evaluated for treatment of pregnant women...

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