Nerve cells in the brain and spinal cord sense pain caused by physical insult

The most common way of managing the pain that accompanies inflammation is to use drugs such as aspirin and ibuprofen. These work by selectively blocking the protein COX2, which functions to produce soluble molecules known as prostaglandins. Although it is known that blocking COX2 in the tissue and in the brain and spinal cord (the CNS) reduces the pain that accompanies inflammation, the relative contribution of COX2 at these two sites to the pain that accompanies inflammation has not been determined...

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