What is the suppressing effect of the PPAR-gamma ligands on stomach cancer cells?
Wednesday, February 18, 2009 - 06:15
in Health & Medicine
PPAR- gamma is manifested in a variety of tissues and cancer cells and the ligands that activate PPAR- PPAR- are currently being studied as a novel treatment. The PPAR-gamma ligand generally decreases the survival rate of cancer cells via differentiation, apoptotic induction, and changes in genes or proteins associated with entrance into the G1/S phase. There have been some reports suggesting that stomach cancer cells manifest PPAR- gamma and are suppressed by the PPAR- gamma ligand. Recently, another report has shown that troglitazone, the ligand of PPAR- gamma, may prove useful in preventive medicine, and this effect is dependent on PPAR- gamma...