Are TACE treatments really well tolerated without any reduction of liver function?

Recently, it has been demonstrated that TACE improves survival compared with best supportive care in meta-analyses of randomised trials and in two individual clinical trials. However, although selective TACE is currently widely used, there are no reported extensive data from large series on both short and long term effects of this treatment on liver function. Equally, because the optimal number of sessions is not known, it is debatable if repeated courses of selective TACE may progressively impair liver function and if they are well tolerated or are limited by major side effects...

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