Antibody targeting the protein FGFR3 inhibits cancer cell growth

Several forms of cancer, including bladder cancer and multiple myeloma caused by the t(4;14) genetic abnormality, are associated with either overexpression or perpetual activation of the protein FGFR3. A team of researchers, at Genentech Inc., South San Francisco, has now generated evidence that FGFR3 might be a good therapeutic target for these diseases and developed an FGFR3-targeted antibody that had potent antitumour activity in mice transplanted with either human bladder cancer cells or t(4;14)-positive multiple myeloma cells...

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