Can animal models of disease reliably inform human studies?

'The value of animal experiments for predicting the effectiveness of treatment strategies in clinical trials has remained controversial, mainly because of a recurrent failure of interventions apparently promising in animal models to translate to the clinic,' say authors in a Research in Translation piece published in PLoS Medicine this week. The PLoS Medicine magazine article by H. van der Worp (University Medicine Centre Utrecht) and colleagues discusses the controversies and possibilities of translating the results of animal experiments into human clinical trials...

Read the whole article on

More from