How Amyloid Plaques May Damage Brain Cells In Alzheimer's Disease

A major question surrounding Alzheimer's disease -- whether and how amyloid plaques found in the brains of patients actually damage neurons -- may be closer to an answer. Using an advanced imaging technique, researchers from the MassGeneral Institute for Neurodegenerative Disease found that levels of intracellular calcium are significantly elevated in neurons close to Alzheimer's plaques in a mouse model and showed how excess calcium may interfere with neuronal signals and cause cell death.

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