New Function For The Protein Bcl-xL: It Prevents Bone Breakdown
Thursday, December 31, 2009 - 15:28
in Health & Medicine
In blood cells, the protein Bcl-xL has a well-characterized role in preventing cell death by a process known as apoptosis. New research has now identified its functions in osteoclasts, cells that slowly breakdown bone (a process known as resorption). Surprisingly, not only does Bcl-xL prevent osteoclast apoptosis in mice, it also negatively regulates the bone-resorbing activity of osteoclasts.