'Vicious circle' offers new acute leukemia treatment target

Researchers have discovered a network of protein and microRNA molecules that, when imbalanced, contributes to abnormally high levels of a protein called KIT and favors the development of acute myeloid leukemia (AML). The researchers therapeutically targeted this network in mice and forced the disease into remission. They believe that targeting this mechanism and reducing the amount of KIT protein will prove to be a more effective therapy for AML than the current standard of care.

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