New laboratory test assesses how DNA damage affects protein synthesis

In transcription genetic information from DNA is copied to messenger RNA for protein production. But anticancer drugs and environmental chemicals can sometimes interrupt this flow of genetic information by causing DNA modifications. Chemists have now developed a test to examine how such DNA modifications lead to aberrant transcription and ultimately a disruption in protein synthesis. The method can help explain how DNA damage arising from anticancer drugs and environmental chemicals leads to cancer development.

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