Scientists target DNA repair to eradicate leukemia stem cells
Sunday, December 9, 2012 - 17:00
in Health & Medicine
Despite treatment with imatinib, which targets chronic myeloid leukemia, some patients may be at risk for relapse because of leukemia stem cells that are resistant to treatment, accumulating additional genetic errors, and leading to disease progression. Researchers have shown they can block leukemia stem cell repair by targeting a protein that cells depend on to fix genetic mistakes. The findings may lead to a new strategy to overcome drug resistance.