Molecule's structure reveals new therapeutic opportunities for rare diabetes
Wednesday, March 13, 2013 - 16:00
in Biology & Nature
Researchers have determined the 3-D structure of a protein called HNF-4±. People with mature onset diabetes of the young (MODY1) have inherited mutations in the HNF-4± protein. This first-ever look at HNF-4±'s full structure uncovers new information about how it functions. The study also reveals new pockets in the protein that could be targeted with therapeutic drugs aimed at alleviating MODY1.