Link between inherited endocrine tumor syndrome and much-studied cell pathway
Wednesday, April 24, 2013 - 12:30
in Health & Medicine
The protein menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. Menin mutations lead to increased Hedgehog signaling and cell proliferation. Researchers found that inhibiting proteins in the Hedgehog network using drugs reduces growth of tumors in mice.