Balancing act: Cell senescence, aging related to epigenetic changes

Cell senescence, an irreversible arrest of proliferation, is thought to be associated with normal aging and is protective against cancer. Researchers found that senescent cells undergo changes in their chromatin, similar to changes in cells that are prematurely aging. When the nuclear protein lamin B1 is deleted in senescent cells, large-scale changes in gene expression occurred. This loss of lamin B1 may cause changes in chromatin architecture and add to premature cell aging.

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