Alzheimer's: Newly identified protein pathology impairs RNA splicing

Researchers have identified a previously unrecognized type of pathology in the brains of patients with Alzheimer's disease. These tangle-like structures appear at early stages of Alzheimer's and are not found in other neurodegenerative diseases such as Parkinson's disease. The appearance of these tangles, which sequester proteins involved in RNA splicing, is linked to widespread changes in Alzheimer's brains compared to healthy brains.

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