Genetic variant that increases testicular cancer risk in caucasians evolved to protect light skin

One of the most important proteins implicated in cancer is p53. Researchers have identified a DNA sequence variation in a p53-binding site that is more prevalent in Caucasians than in Africans and is associated with a very large risk of testicular cancer but may protect light-skinned individuals against harmful ultraviolet rays. The study offers insights into the evolution of DNA sequence variations in p53-binding sites, and it could lead to improvements in personalized treatment strategies.

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