Defect in Ikaros gene mimics human B cell leukemia

Researchers investigated the differentiation of stem cells to mature B cells, and now present, for the first time, molecular details on the role of the Ikaros gene during early B cell development. A defect in Ikaros function causes an early block in B-lymphopoiesis and prevents the development of mature B cells. The cells stay in an aberrant state, which closely resembles that of cells in B-ALL, a special form of human B cell leukemia.

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