Blood cells reprogrammed into blood stem cells in mice

Researchers have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells, using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells are able to self-renew like HSCs and can give rise to all of the cellular components of the blood like HSCs. The findings mark a significant step toward a major goal of regenerative medicine: the ability to produce HSCs suitable for hematopoietic stem cell transplantation from other cell types.

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