Role of calcium in familial Alzheimer's disease clarified, pointing to new therapeutics
Wednesday, May 14, 2014 - 05:31
in Biology & Nature
Mutations in two presenilin proteins associated with familial Alzheimer's disease disrupt the flow of calcium ions within neurons. Researchers have found that suppressing the hyperactivity of the calcium channels alleviated FAD-like symptoms in mice models of the disease. These new observations suggest that approaches based on modulating calcium signaling could be explored for new AD therapies.