Opening-up the stem cell niche: Hematopoietic stem cell transplantation without irradiation

A novel mouse model allows for the transplantation of human blood-forming stem cells without the need for irradiation therapy. The results show that the Kit receptor is important for the function of human blood stem cells, notably in a transplantation setting. Further studies will now focus on using this knowledge about the role of the receptor to improve conditioning therapy in the setting of therapeutic hematopoietic stem cell transplantation in patients.

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