Mouse model that reproduces noonan syndrome created
Thursday, November 6, 2014 - 04:32
in Health & Medicine
A single mutation in the mouse genome -- within the K-Ras gene -- reproduces the main alterations found in humans of this rare syndrome, which include short stature, facial dysmorphia, cardiac dysfunction and haematological alterations. Researchers are able to prevent the development of symptoms via prenatal treatment with MEK inhibitors The discovery opens avenues to novel therapeutic strategies for the disease.