Accumulation of a product of cell metabolism found to be linked with kidney tumor growth
Wednesday, August 31, 2016 - 14:31
in Health & Medicine
Researchers have shown that when the metabolite fumarate accumulates in a hereditary form of renal cancer it leads to an epigenetic reprogramming that drives cancer. The tumor growth mechanism seen here could be similar in other cancers, such as lung and bowel cancer, where the enzyme that breaks down fumarate is not present or not fully functional.