Gram-negative bacteria may influence Alzheimer's disease pathology

For the first time, researchers have found higher levels of Gram-negative bacteria antigens in brain samples from late-onset Alzheimer’s disease patients. Compared to controls, patients with Alzheimer's had much higher levels of lipopolysaccharide (LPS) and E coli K99 pili protein. In addition, the research team also found LPS molecules congregated with amyloid plaques, which have been linked to Alzheimer’s pathology and progression.

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