Engineering 'hairpins' increases CRISPR accuracy
Monday, April 15, 2019 - 14:40
in Biology & Nature
Biomedical engineers have developed a method for improving the accuracy of the CRISPR genome editing technology by an average of 50-fold. The approach adds a short tail to the guide RNA that folds back and binds onto itself, creating a 'lock' that can only be undone by the targeted DNA sequence.