Scientists propose new theory on Alzheimer's, amyloid connection
Tuesday, April 23, 2019 - 14:20
in Biology & Nature
'Is amyloid precursor protein the mastermind behind Alzheimer's or is it just an accomplice?' Researchers devised a multi-functional reporter for amyloid precursor protein and tracked its localization and mobility, noticing a strange association between the protein and cholesterol that resides in the cell membrane of synapses. With cholesterol's broad involvement in almost all aspects of neurons' life, they propose a new theory on the amyloid precursor protein connection in AD, especially in the surface of those tiny synapses, which triggers neurodegeneration.