Un-natural mRNAs modified with sulfur atoms boost efficient protein synthesis
Thursday, July 16, 2020 - 13:11
in Physics & Chemistry
A group of scientists has succeeded in the development of modified messenger RNAs (mRNAs) that contain sulfur atoms in the place of oxygen atoms of phosphate moieties of natural mRNAs. They discovered that modified mRNAs accelerated the initiation step of the translation reactions and improved efficiency of protein synthesis by at least 20 times compared with that using natural-form mRNAs.