Fatostatin Molecule Is Turnoff For Fat-Making Genes
Friday, August 28, 2009 - 23:57
in Health & Medicine
A small molecule known as 125B11 but also called Fatostatin and reportedly having both anti-fat and anti-cancer abilities is also a literal turnoff for fat-making genes, according to a new report in the journal Chemistry and Biology. The chemical blocks transcription factor known SREBP, a master controller of fat synthesis. That action in mice that are genetically prone to obesity causes the animals to become leaner. It also lowers the amount of fat in their livers, along with their blood sugar and cholesterol levels. Fatostatin or its analogs may also serve a tool for gaining further insights into the regulation of SREBP and fat metabolism read more
