Epigenetic Signatures Consistent In Metastases Of 13 Prostate Cancer Victims
Wednesday, January 23, 2013 - 16:40
in Health & Medicine
In a genome-wide analysis of 13 metastatic prostate cancers done on men who died of metastatic prostate cancer and whose tissue samples were collected after a rapid autopsy, scientists found consistent epigenetic signatures across all metastatic tumors in each patient. The discovery of stable epigenetic marks that sit on the nuclear DNA of cancer cells and alter gene expression, defies a prevailing belief that the marks vary so much within each individual's widespread cancers that they have little or no value as targets for therapy or as biomarkers for treatment response and predicting disease severity. read more