Dismantling Pancreas Cancer's Armor

SEATTLE – Pancreas cancer is notoriously impervious to treatment and resists both chemotherapy and radiotherapy. It has also been thought to provide few targets for immune cells, allowing tumors to grow unchecked. But new research from Fred Hutchinson Cancer Research Center shows that pancreas cancer "veils" itself from the immune system by recruiting specialized immune suppressor cells. The research team also found that removing these cells quickly triggers a spontaneous anti-tumor immune response. The findings, published Feb. 20 in Gut, give hope for future immunotherapy strategies against this deadly and aggressive cancer. read more

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