So What's Wrong With Modern Drug Theory?
Monday, November 17, 2014 - 20:00
in Biology & Nature
While the use of IC50’s is a huge problem in the biological sciences, Academia, Industry and Regulatory bodies have good reason to avoid the established field of enzyme kinetics. As I said in the last post, the problem with IC50 values is that they strip away or obscure finer details of molecular interactions producing an artificial wall on the amount of information we can obtain from biological systems. However, the perception is that modern enzyme kinetic drug studies do not provide a significant improvement in our understanding relative to the increase in resources that are required to do the studies. read more