Scientists visualize how a vital hepatitis C virus protein moves along its nucleic acid substrate

In a series of three snapshots that recapitulate the coordinated actions, scientists reveal how a protein essential for the replication of the hepatitis C virus moves along its nucleic acid substrate. The finding illustrates the nucleotide-dependent changes of interactions between the protein, known as NS3, and DNA, work that suggests some of the most feasible strategies to date to block the action of this largely unexplored drug target.

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