Fly study uncovers molecular link between obesity and heart disease
Tuesday, November 2, 2010 - 12:00
in Health & Medicine
It's no secret that obesity is hard on the heart. More than 30 percent of Americans are obese, and many of them are also at increased risk for cancer, diabetes and heart disease. However, there are numerous causes of obesity and other risk factors for each of these conditions, making it difficult to tease them apart. At Sanford-Burnham Medical Research Institute (Sanford-Burnham), a team led by Sean Oldham, Ph.D., and Rolf Bodmer, Ph.D., recently created a simple model to link high-fat diet, obesity and heart dysfunction. Using fruit flies, they discovered that a protein called TOR influences fat accumulation in the heart.