Why are T cells tolerant to hepatitis B virus?
Tuesday, October 14, 2008 - 17:21
in Health & Medicine
The level of PD-1 expression has been proved by recent studies to be positively correlated with the extent of HBV-specific T cell impairments. However, the degree of T cell exhaustion which affects the disease statuses of hepatitis B patients has so far been only evaluated in restricted and small groups of patients between those with established chronicity and subjects with acute HBV infection. Besides, whether levels of PD-1 expression on T cells differ between acute exacerbation of hepatitis B and chronic HBV infected patients is still unknown.