Research Yields Unprecedented Insight into Antiviral Immune Response

Researchers from UMDNJ-Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, show, for the first time, the structure of retinoic-acid-inducible gene-I, or RIG-I. RIG-I is a human protein that detects whether the RNA comes from a virus (viral RNA) and, if so, initiates an auto-immune response. Isolating the structure of RIG-I with RNA bound is the first step in developing broad-based therapies against viral infections.

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