Interaction between gene variants may alter brain function in schizophrenia

A collaborative study led by investigators from Massachusetts General Hospital (MGH) is giving what may be the first look at how interactions between genes underlie a key symptom of schizophrenia, impaired working memory. Functional imaging studies reveal how a combination of common variants in two genes is associated with reduced activity of important brain structures in schizophrenia patients but not in normal controls. The report has been released online in the Early Edition of the Proceedings of the National Academy of Sciences.

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