Modification of mutant huntingtin protein increases its clearance from brain cells

A new study has identified a potential strategy for removing the abnormal protein that causes Huntington's disease (HD) from brain cells, which could slow the progression of the devastating neurological disorder. In the April 3 issue of Cell, a team of researchers from the MassGeneral Institute for Neurodegenerative Disease (MGH-MIND) describes how an alteration to the mutated form of the huntingtin protein appears to accelerate its breakdown and removal through normal cellular processes.

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