The indefinite self-renewal of specialized cells without the need for stem cell intermediates

(PhysOrg.com) -- Is the indefinite expansion of adult cells possible without recourse to stem cell intermediates? The team led by Michael Sieweke at the Centre d'immunologie de Marseille Luminy, France has proved that this is the case by achieving the ex vivo regeneration for several months of macrophages, specialized cells in the immune system. Published in Science on November 6, 2009, this discovery could be applied to other cell types.

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