Does Glutathione-S-transferase associate with gastrointestinal cancer in Korean population?

The glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null genotypes have been linked to increased risk of developing cancer. The results regarding the association between GSTM1 and GSTT1 null genotypes and the risk of GC or CRC were contradictory. However, the majority of previous reports are limited by their small sample sizes. Therefore, the association of the GSTM1/GSTT1 null genotype with the risk of GC and CRC need to be confirmed in studies with larger numbers of samples.

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