Nonspecific marker of non-erosive reflux disease

Non-erosive reflux disease (NERD) is the most common disorders of the gastrointestinal tract. However, diagnosis of NERD is not objective. A research group in China investigated esophageal mucosal damage in response to various factors, and revealed that acute stress and aspirin induced dilated intercellular spaces (DIS) in esophagus uncorrelated with acid reflux, suggesting that DIS is a nonspecific marker of NERD.

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