HSP-90 and vasoregulation in portal hypertension

A research team from Germany investigated the role of heat shock protein-90 (HSP-90) in neuronal NO-synthase (nNOS)-function and vasoregulation in the mesenteric vasculature. Their results showed that interaction and co-localization of nNOS and HSP-90 are evidenced. The inhibition of HSP-90 largely ameliorates enhanced nNOS-mediated vasodilation in portal hypertension making HSP-90 a potential therapeutic target during portal hypertension.

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