Low Oxygen Recruits Inflammatory Cells to Tumors, Stimulating Growth

(PhysOrg.com) -- The inner regions of tumors have a low-oxygen content and often contain inflammatory cells called macrophages, which researchers suspect promote tumor growth. Now, University of Pennsylvania School of Medicine researchers show that this is the case: Tumor cells in this low-oxygen area actively recruit macrophages and blocking their recruitment reduces tumor growth and aggressiveness in mouse models. The results suggest new targets for cancer drug development.

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