Improving Kinase Inhibitors: Molecular editing of resorcylic acid lactones
Tuesday, June 8, 2010 - 07:00
in Biology & Nature
(PhysOrg.com) -- Given the great number and wide range of biological activities they regulate, kinases are among the most important enzyme targets for drug development efforts, particularly in the field of oncology. One of the main challenges faced by researchers in this area is inhibitor specificity; many compounds that effectively block the activity of a given target kinase also show significant inhibition of other kinases.