Uncapping the mystery behind the mechanism of cap removal from actin filaments

In this study, Shuichi Takeda at Nagoya University and colleagues present the X-ray crystal structures of the actin capping protein (CP) complexed with its inhibitors, V-1 and CARMIL, and demonstrate that the two regulators modulate the filament capping activity in very different manners. These findings will be published next week in the online, open access journal PLoS Biology.

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